Socorro Juarez, dressed as a giant vaccine syringe, dances with Rosa Cardona, dressed as a coronavirus, in San Juan Capistrano on Feb. 25 to encourage fellow Latinos to get vaccinated and boosted. (Robert Gauthier/Los Angeles Times)

Los Angeles County residents who are at least 50 years old can receive a second COVID-19 booster shot starting Wednesday, officials announced.

The additional booster doses — which amount to a fourth shot for those who originally got the Pfizer-BioNTech or Moderna vaccines, or a third jab for recipients of the Johnson & Johnson vaccine — are available to those who are at least four months removed from their initial booster.

A number of sites countywide will open initially to accommodate those seeking a second booster, and other locations may soon be available as well.

L.A. County is moving aggressively to offer the additional shots, which the U.S. Food and Drug Administration only officially authorized Tuesday for those age 50 and older. The timeline in other counties was not immediately clear.

Here’s what we know:

Where can I get a second booster?

L.A. County health officials said second booster doses will be available starting Wednesday at the following locations:

Eugene A. Obregon Park in East L.A.

Ted Watkins Memorial Park in South L.A.

Balboa Sports Complex in Encino

Commerce Senior Citizens Center

Market Street Center in Santa Clarita

Palmdale Oasis Park Recreation Center

Norwalk Arts and Sports Complex

More information on these and other vaccination sites is available at

Are there other options?

Officials said the additional boosters might soon be available from other providers, such as pharmacies and doctor’s offices, but those interested should check ahead.

Kaiser Permanente said Tuesday afternoon it was waiting for additional clinical guidance from the CDC, and will need to adjust its computer systems, before it can begin offering the second booster shot.

“As we have throughout the pandemic, when the Centers for Disease Control issues clinical guidance, Kaiser Permanente will administer second booster doses according to that guidance, and as soon as our systems and processes can be updated to safely administer these doses to the correct populations,” Kaiser said in a statement.

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“It is important to note that the FDA also reiterated that data show an initial booster dose is critical in helping to protect all adults from the potentially severe outcomes of COVID-19,” that statement continued. “Those who have not received their initial booster dose are strongly encouraged to do so.”

Why is this happening now?

“Current evidence suggests some waning of protection over time against serious outcomes from COVID-19 in older and immunocompromised individuals,” said Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement. “Based on an analysis of emerging data, a second booster dose of either the Pfizer-BioNTech or Moderna COVID-19 vaccine could help increase protection levels for these higher-risk individuals.”

The CDC has already recommended that people age 12 and older with moderate or severely compromised immune systems who originally got the Pfizer or Moderna vaccination shot get a fourth dose of vaccine, and those with such weakened immune systems who originally got the single-shot Johnson & Johnson vaccine to get two additional doses.

What are experts saying about when to get jabbed?

Dr. Peter Chin-Hong, a UC San Francisco infectious diseases expert, said in an interview that if he were advising his relatives, he might want those age 65 and older — and especially those 75 and older — to get the second booster shot.

Getting a second booster shot is less urgent for a relatively healthy person in their 50s, Chin-Hong said. But a second booster shot would allow them to get an antibody boost that may help “protect them against getting a breakthrough infection,” Chin-Hong said.

Such a fourth dose might be helpful for people who are traveling to, say, a wedding or another country, and want to take additional steps to avoid getting infected.

It will take more time for researchers to determine how much additional benefit people will get from a fourth dose of vaccine. Clearly, there’s a big benefit after a second dose, and again following the first booster, Chin-Hong said. Early data from Israel, however, suggest the additional benefit after the second booster isn’t as substantial.

But the second booster may still be worth getting, and, especially for older people, potentially lifesaving. The second booster is safe, Chin-Hong said: “You don’t get immune exhaustion, you don’t get more side effects. It’s well-tolerated.”

Added Dr. Robert Kim-Farley, a UCLA epidemiologist and infectious disease expert: “We do note waning immunity following the third dose. And in some studies, a fourth dose has been able to bring the antibody level back up to what it was shortly after the third dose. That would imply additional protection,” Kim-Farley said in an interview.

Dr. Robert Wachter, chair of UC San Francisco’s Department of Medicine, said in a tweet Tuesday that he recommends getting the booster for those who are older or those at higher risk. It’s more of a toss-up for those at lower risk, but Wachter added that he thought the second booster would still be beneficial for them.

This story originally appeared in Los Angeles Times.

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